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Countercurrent distribution (CCD, also spelled "counter current" distribution) is an analytical chemistry technique which was developed by Lyman C. Craig in the 1940s. [1] Countercurrent distribution is a separation process that is founded on the principles of liquid–liquid extraction where a chemical compound is distributed (partitioned ...
Lyman C. Craig (born 1906 in Palmyra Township, Warren County, Iowa; died 1974) was a chemical researcher who worked at The Rockefeller Institute for Medical Research from 1933 onward. [1] In 1944 he published a seminal work on countercurrent distribution , which became an important separation technique. [ 2 ]
Countercurrent chromatography usually uses a planetary gear motion without rotary seals, while centrifugal partition chromatography uses circular rotation with rotary seals for liquid connection. CCC has interchanging mixing and settling zones in the coil tube, so atomization, extraction and settling are time and zone separated.
A high-performance countercurrent chromatography system. Countercurrent chromatography (CCC, also counter-current chromatography) is a form of liquid–liquid chromatography that uses a liquid stationary phase that is held in place by inertia of the molecules composing the stationary phase accelerating toward the center of a centrifuge due to centripetal force [1] and is used to separate ...
Droplet countercurrent chromatography (DCCC or DCC) was introduced in 1970 by Tanimura, Pisano, Ito, and Bowman. [1] DCCC is considered to be a form of liquid-liquid separation, which includes countercurrent distribution and countercurrent chromatography, that employs a liquid stationary phase held in a collection of vertical glass columns connected in series.
A countercurrent of the gas is stimulated either mechanically or (less preferred) by a temperature gradient between the top and bottom of the rotor. With a countercurrent-to-feed ratio of 4, Glaser [3] calculates a separation factor of 1,74 for a TC-21 centrifuge of 5 m height. Lowering this ratio (by increasing the feed) decreases the ...
A separatory funnel used for liquid–liquid extraction, as evident by the two immiscible liquids.. Liquid–liquid extraction, also known as solvent extraction and partitioning, is a method to separate compounds or metal complexes, based on their relative solubilities in two different immiscible liquids, usually water (polar) and an organic solvent (non-polar).
In manufacturing, the simulated moving bed (SMB) process is a highly engineered process for implementing chromatographic separation. It is used to separate one chemical compound or one class of chemical compounds from one or more other chemical compounds to provide significant quantities of the purified or enriched material at a lower cost than could be obtained using simple (batch ...
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