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Phosphatidylserine (abbreviated Ptd-L-Ser or PS) is a phospholipid and is a component of the cell membrane. [1] It plays a key role in cell cycle signaling, specifically in relation to apoptosis . It is a key pathway for viruses to enter cells via apoptotic mimicry . [ 2 ]
Phosphatidylserine decarboxylase is the enzyme that is used to decarboxylate phosphatidylserine in the first pathway. The phosphatidylserine decarboxylation pathway is the main source of synthesis for phosphatidylethanolamine in the membranes of the mitochondria. Phosphatidylethanolamine produced in the mitochondrial membrane is also ...
In enzymology, a CDP-diacylglycerol—serine O-phosphatidyltransferase (EC 2.7.8.8) is an enzyme that catalyzes the chemical reaction CDP-diacylglycerol + L-serine ⇌ {\displaystyle \rightleftharpoons } CMP + (3-sn-phosphatidyl)-L-serine
L-serine-phosphatidylethanolamine phosphatidyltransferase (EC 2.7.8.29, phosphatidylserine synthase 2, serine-exchange enzyme II, PTDSS2 (gene)) is an enzyme with systematic name L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase. [1] [2] This enzyme catalyses the following chemical reaction
The phosphate serves as a link to another alcohol-usually ethanolamine, choline, serine, or a carbohydrate. The identity of the alcohol determines the subcategory of the phosphatidate. There is a negative charge on the phosphate and, in the case of choline or serine, a positive quaternary ammonium ion. (Serine also has a negative carboxylate ...
The conversion of PA into diacylglycerol (DAG) by LPPs is the commitment step for the production of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylserine (PS). In addition, DAG is also converted into CDP-DAG, which is a precursor for phosphatidylglycerol (PG), phosphatidylinositol (PI) and phosphoinositides (PIP, PIP 2 ...
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