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[53] [45] In one survey of over 9,000 patients taking cimetidine, gynecomastia was the most frequent endocrine-related complaint but was reported in only 0.2% of patients. [45] At high doses however, such as those used to treat Zollinger–Ellison syndrome, there may be a higher incidence of gynecomastia with cimetidine. [53]
In addition, gynecomastia occurred in 0.1% to 0.5% of men treated for non-hypersecretory conditions with cimetidine for 1 month or longer and in about 2% of men treated for pathologic hypersecretory conditions; in even fewer men, cimetidine may also cause loss of libido, and impotence, all of which are reversible upon discontinuation. [9]
If the condition does not resolve within 2 years, or if it causes embarrassment, pain or tenderness, treatment is warranted. [11] [12] Medical treatment of gynecomastia that has persisted beyond two years is often ineffective. Gynecomastia is different from "pseudogynecomastia", [5] [6] which is commonly present in men with obesity. [13] [14]
Other drugs that have been associated with mammoplasia include D-penicillamine, bucillamine, neothetazone, ciclosporin, indinavir, marijuana, and cimetidine. [6] [27] A 1997 study found an association between the SSRIs and mammoplasia in 23 (39%) of its 59 female participants. [26] Studies have also found associations between SSRIs and ...
“What’s different is what the drug actually does for you, which is: I don’t feel like I’m dieting,” the Mrs. Doubtfire star said. “I feel like a normal person. “I feel like a normal ...
Santa Claus’ suit may be one of his immutable features today, but he didn’t always wear red — and his closet used to be much more expansive. The legendary gift-giver’s style is just one ...
Hints and the solution for today's Wordle on Wednesday, December 11.
Enzyme inhibitors – May cause increased levels of testosterone: Nefazodone, fluoxetine, paroxetine (antidepressants), itraconazole, fluconazole, and other azole antifungals, cimetidine (an anti-ulcer agent that can cause gynecomastia in men because of this effect). Clarithromycin and other macrolide antibiotics, and protease inhibitors (HIV ...
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