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In the first stage of sexual reproduction, meiosis, the number of chromosomes is reduced from a diploid number (2n) to a haploid number (n). During fertilisation , haploid gametes come together to form a diploid zygote , and the original number of chromosomes is restored.
Mechanically, the process is similar to mitosis, though its genetic results are fundamentally different. The result is the production of four haploid cells (n chromosomes; 23 in humans) from the two haploid cells (with n chromosomes, each consisting of two sister chromatids) [clarification needed] produced in meiosis I. The four main steps of ...
This process results in each gamete usually containing a mixture of chromosomes from both original parents. Improper chromosome segregation (see non-disjunction, disomy) can result in aneuploid gametes having either too few or too many chromosomes. The second stage at which segregation occurs during meiosis is prophase II (see meiosis diagram ...
The two chromosomes which pair are referred to as non-sister chromosomes, since they did not arise simply from the replication of a parental chromosome. Recombination between non-sister chromosomes at meiosis is known to be a recombinational repair process that can repair double-strand breaks and other types of double-strand damage. [2]
Crossing over is important for the normal segregation of chromosomes during meiosis. [2] Crossing over also accounts for genetic variation, because due to the swapping of genetic material during crossing over, the chromatids held together by the centromere are no longer identical. So, when the chromosomes go on to meiosis II and separate, some ...
Non-random segregation of chromosomes is a deviation from the usual distribution of chromosomes during meiosis, that is, during segregation of the genome among gametes.While usually according to the 2nd Mendelian rule (“Law of Segregation of genes“) homologous chromosomes are randomly distributed among daughter nuclei, there are various modes deviating from this in numerous organisms that ...
The development of sexual differences begins with the XY sex-determination system that is present in humans, and complex mechanisms are responsible for the development of the phenotypic differences between male and female humans from an undifferentiated zygote. [3] Females typically have two X chromosomes, and males typically have a Y ...
In eukaryotes, such as humans, roughly 3.2 billion nucleotides are spread out over 23 different chromosomes (males have both an X chromosome and a Y chromosome instead of a pair of X chromosomes as seen in females). Each chromosome consists enormously long linear DNA molecule associated with proteins that fold and pack the fine thread of DNA ...