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Bone remodeling is a process which maintains bone strength and ion homeostasis by replacing discrete parts of old bone with newly synthesized packets of proteinaceous matrix. [5] Bone is resorbed by osteoclasts, and is deposited by osteoblasts in a process called ossification. [6] Osteocyte activity plays a key role in this process. Conditions ...
Bone tissue is removed by osteoclasts, and then new bone tissue is formed by osteoblasts. Both processes utilize cytokine (TGF-β, IGF) signalling.In osteology, bone remodeling or bone metabolism is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation).
Bones may weaken to such a degree that a break may occur with minor stress or spontaneously. After the broken bone heals, some people may have chronic pain and a decreased ability to carry out normal activities. [3] Osteoporosis may be due to lower-than-normal maximum bone mass and greater-than-normal bone loss.
Both of these conditions, deficiency and excess, can lead to tissue injury and disease. However, due to homeostatic regulation, the human body is capable of balancing a wide range of copper intakes for the needs of healthy individuals. [46] Many aspects of copper homeostasis are known at the molecular level. [47]
Osteomalacia is a disease characterized by the softening of the bones caused by impaired bone metabolism primarily due to inadequate levels of available phosphate, calcium, and vitamin D, or because of resorption of calcium. The impairment of bone metabolism causes inadequate bone mineralization.
In addition to supporting and giving structure to the body, a bone is the major reservoir for many minerals and compounds essential for maintaining a healthy pH balance. [5] The deterioration of the body with age renders the elderly particularly susceptible to and affected by poor bone health.
The plasma total calcium concentration is in the range of 2.2–2.6 mmol/L (9–10.5 mg/dL), and the normal ionized calcium is 1.3–1.5 mmol/L (4.5–5.6 mg/dL). [4] The amount of total calcium in the blood varies with the level of plasma albumin, the most abundant protein in plasma, and therefore the main carrier of protein-bound calcium in the blood.
Homeostatic capacity refers to the capability of systems to self-stabilize in response to external forces or stressors, or more simply the capability of systems to maintain homeostasis. [ 1 ] [ 2 ] For living organisms , it is life's foundational trait, consisting of a hierarchy and network of traits endowed by nature and shaped by natural ...