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Additional researched vinca alkaloids include vincaminol, vineridine, and vinburnine. Vinpocetine is a semi-synthetic derivative of vincamine (sometimes described as "a synthetic ethyl ester of apovincamine"). [14] Minor vinca alkaloids include minovincine, methoxyminovincine, minovincinine, vincadifformine, desoxyvincaminol, and vincamajine ...
1.08 Vinca alkaloids: Vinblastine: IV: Microtubule assembly inhibitor. Arrests cells in M phase. Hodgkin lymphoma, germ cell tumours, non-small cell lung cancer, bladder cancer and primary immune thrombocytopenia: Neurotoxicity, myelosuppression, myocardial ischaemia (rare) and myocardial infarction (rare). Vincristine: IV: As above.
Vincamine is a monoterpenoid indole alkaloid found in the leaves of Vinca minor (lesser periwinkle), comprising about 25–65% of its indole alkaloids by weight. It can also be synthesized from related alkaloids. [1]
Vinca alkaloids were originally manufactured by extracting them from Catharanthus roseus (Madagascar Periwinkle). [1] Podophyllum spp. Two chemotherapy drugs, etoposide and teniposide, are synthetic chemical compounds similar in chemical structure to the toxin podophyllotoxin which is found in Podophyllum peltatum (May Apple). [1] Taxus brevifolia
In traditional Chinese medicine, extracts from it have been used against numerous diseases, including diabetes, malaria, and Hodgkin's lymphoma. [22] [13] In the 1950s, vinca alkaloids, including vinblastine and vincristine, were isolated from Catharanthus roseus while screening for anti-diabetic drugs. [23]
Vinblastine is a vinca alkaloid [9] [2] [10] and a chemical analogue of vincristine. [11] [12] It binds tubulin, thereby inhibiting the assembly of microtubules. [13]Vinblastine treatment causes M phase specific cell cycle arrest by disrupting microtubule assembly and proper formation of the mitotic spindle and the kinetochore, each of which are necessary for the separation of chromosomes ...
Meaning Origin language and etymology Example(s) -iasis: condition, formation, or presence of Latin -iasis, pathological condition or process; from Greek ἴασις (íasis), cure, repair, mend mydriasis: iatr(o)-of or pertaining to medicine or a physician (uncommon as a prefix but common as a suffix; see -iatry)
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