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Cyclobenzaprine, sold under several brand names including, historically, Flexeril, is a muscle relaxer used for muscle spasms from musculoskeletal conditions of sudden onset. [5] It is not useful in cerebral palsy. [5] It is taken by mouth. [5] Common side effects include headache, feeling tired, dizziness, and dry mouth. [5]
Cyclobenzaprine produces confusion and lethargy, as well as anticholinergic side effects. When taken in excess or in combination with other substances, it may also be toxic . While the body adjusts to this medication, it is possible for patients to experience dry mouth , fatigue , lightheadedness, constipation or blurred vision .
Another class of antispasmodics for such treatment includes cyclobenzaprine, carisoprodol, diazepam, orphenadrine, and tizanidine. [7] Meprobamate is another effective antispasmodic which was first introduced for clinical usage in 1955 mainly as an anxiolytic and soon afterward became a blockbuster psychotropic drug.
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[medical citation needed] Elucidation of the exact mechanism of action is ongoing but there is limited study due to the existence of more effective, safe muscle relaxants (e.g., diazepam, cyclobenzaprine, tizanidine), greatly limiting the potential benefit of identifying novel compounds which share chlorzoxazone's mechanism of action.
Orphenadrine (sold under many brand names) [1] is an anticholinergic drug of the ethanolamine antihistamine class; it is closely related to diphenhydramine.It is a muscle relaxant that is used to treat muscle pain and to help with motor control in Parkinson's disease, but has largely been superseded by newer drugs.
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Specifically, in one study, compared to fasted conditions, the presence of food at the time of drug administration increased C max by 77.5%, AUC 0-t by 23.5%, and AUC 0-∞ by 15.4%. [4] Metaxalone is a substrate of CYP1A2 and CYP2C19 , an inhibitor of CYP1A2 , CYP2B6 , CYP2C9 , CYP2C19 , CYP2D6 , CYP2E1 , and CYP3A , and an inducer of CYP1A2 ...
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261