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Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium complex, leprosy, and Legionnaires' disease. [3]
Rifampin rapidly kills fast-dividing bacilli strains as well as "persisters" cells, which remain biologically inactive for long periods of time that allow them to evade antibiotic activity. [7] In addition, rifabutin and rifapentine have both been used against tuberculosis acquired in HIV-positive patients.
Toolstation was formed in February 2003 by Mark Goddard-Watts, one of the founding family members of Screwfix Direct. [3] In 2012 Goddard-Watts sold his shares to Travis Perkins plc. [4] [5] [6] A distribution centre in Middleton, Greater Manchester opened in August 2018. [7] In 2019 Toolstation opened their 400th store, in Balham. [8]
Day 1: INH at 1/3 or 1/4 dose; Day 2: INH at 1/2 dose; Day 3: INH at full dose; Day 4: RMP at 1/3 or 1/4 dose; Day 5: RMP at 1/2 dose; Day 6: RMP at full dose; Day 7: EMB at 1/3 or 1/4 dose; Day 8: EMB at 1/2 dose; Day 9: EMB at full dose; No more than one test dose per day should be given, and all other drugs should be stopped while test ...
These may include poor coordination, loss of appetite, nausea, joint pain, feeling tired, and numbness. [2] Severe side effects include liver problems. [3] Use in those under the age of 15 may not be appropriate. [3] It is unclear if use in pregnancy is safe for the baby. [3]
Rifapentine, sold under the brand name Priftin, is an antibiotic used in the treatment of tuberculosis. [2] In active tuberculosis it is used together with other antituberculosis medications. [2] In latent tuberculosis it is typically used with isoniazid. [2] It is taken by mouth. [2]
Scientists at the Italian drug company Achifar discovered rifabutin in 1975. (Eventually Archifar became part of Farmitalia Carlo Erba, a unit of the conglomerate Montedison which was subsequently bought by Pharmacia) This company's Adria Laboratories subsidiary filed for Food and Drug Administration (FDA) approval of rifabutin under the brand name Mycobutin in the early 1990s and the drug ...
Up to March 2024, Toolstation had continued to grow its UK market share, opening 163 new Toolstation branches between 2020 and 2022, and adding seven more in 2023. However, its mainland Europe stores were doing less well, and Travis Perkins announced Toolstation was quitting France and reviewing its operations in Netherlands and Belgium. [30]