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The lacuna are situated between the lamellae, and consist of a number of oblong spaces. In an ordinary microscopic section, viewed by transmitted light, they appear as fusiform opaque spots. Each lacuna is occupied during life by a branched cell, termed an osteocyte, bone-cell or bone-corpuscle.
Isogenous groups differentiate into individual chondrocytes where they continue to produce and deposit extracellular matrix (ECM), lengthening the cartilage and increasing its diameter.
The number of chondrocyte cells created and their maturation process can be influenced by multiple different genes and proteins. Two proteins, bone morphogenetic protein 4 (BMP-4) and fibroblast growth factor 2 (FGF2) have been seen to influence the amount of differentiation into chondrocytes. [ 4 ]
Lacuna (histology), a small space containing an osteocyte in bone, or chondrocyte in cartilage Muscular lacuna , a lateral compartment of the thigh Vascular lacuna , a medial compartment beneath the inguinal ligament
In embryogenesis, the skeletal system is derived from the mesoderm germ layer. Chondrification (also known as chondrogenesis) is the process by which cartilage is formed from condensed mesenchyme tissue, which differentiates into chondroblasts and begins secreting the molecules (aggrecan and collagen type II) that form the extracellular matrix.
Arthroscopic image of a central triangular fibrocartilage complex (TFCC) tear. X-ray: X-rays of the wrist are made in two directions: posterior-anterior (PA) and lateral. Radiographs are useful to diagnose or rule out possible bone fractures, a positive ulnar variance or osteoarthritis. The TFCC is not visible on an X-ray, regardless of its ...
A 75-year-old man with a genetic predisposition for Alzheimer’s has yet to show signs of the disease. Could this offer insights on new preventive and therapeutic avenues?
Eventually, the loss of hyaline cartilage matrix and reduction in the chondrocyte content of the hyaline cartilage matrix results in the development of joint disease such as osteoarthritis. Overexpression of hyaline-cartilage specific anabolic factors, such as FGF18, appears to restore the balance between cartilage loss and generation. [15] [16]