Search results
Results from the WOW.Com Content Network
It is postulated that autoantibodies are formed against aminoacyl-tRNA synthetases. The synthetases may be involved in recruiting antigen-presenting and inflammatory cells to the site of muscle or lung injury. The specific molecular pathway of the process awaits elucidation. [18]
The synthetase first binds ATP and the corresponding amino acid (or its precursor) to form an aminoacyl-adenylate, releasing inorganic pyrophosphate (PPi).The adenylate-aaRS complex then binds the appropriate tRNA molecule's D arm, and the amino acid is transferred from the aa-AMP to either the 2'- or the 3'-OH of the last tRNA nucleotide (A76) at the 3'-end.
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis [7]
Isoleucyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the IARS1 gene. [5] [6] Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among ...
An aminoacyl-tRNA, with the tRNA above the arrow and a generic amino acid below the arrow. Most of the tRNA structure is shown as a simplified, colorful ball-and-stick model; the terminal adenosine and the amino acid are shown as structural formulas. The arrow indicates the ester linkage between the amino acid and tRNA.
16 234734 Ensembl ENSG00000090861 ENSMUSG00000031960 UniProt P49588 Q8BGQ7 RefSeq (mRNA) NM_001605 NM_146217 RefSeq (protein) NP_001596 NP_666329 Location (UCSC) Chr 16: 70.25 – 70.29 Mb Chr 8: 111.76 – 111.78 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Alanyl—tRNA synthetase 1 (AARS1) is an enzyme that is encoded by the AARS1 gene in humans and is a member of the aminoacyl ...
The aminoacyl-tRNA synthetases catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology. [1] The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II.
104458 Ensembl ENSG00000113643 ENSMUSG00000018848 UniProt P54136 Q9D0I9 RefSeq (mRNA) NM_002887 NM_025936 RefSeq (protein) NP_002878 NP_080212 Location (UCSC) Chr 5: 168.49 – 168.52 Mb Chr 11: 35.7 – 35.73 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Arginyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the RARS gene. Aminoacyl-tRNA synthetases ...