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[3] [10] [9] Many papain-like protease enzymes function as monomers, though a few, such as cathepsin C (Dipeptidyl-peptidase I), are homotetramers. The mature monomer structure is characteristically divided into two lobes or subdomains, known as the L-domain ( N-terminal ) and the R-domain ( C-terminal ), where the active site is located ...
Cancer, Cathepsin D is a mitogen and "it attenuates the anti-tumor immune response of decaying chemokines to inhibit the function of dendritic cells". Cathepsins B and L are involved in matrix degradation and cell invasion. [3] Stroke [4] Traumatic brain injury [5] Alzheimer's disease [6] Arthritis [7]
Cathepsin L1 is a protein that in humans is encoded by the CTSL1 gene. [ 3 ] [ 4 ] [ 5 ] The protein is a cysteine cathepsin , a lysosomal cysteine protease that plays a major role in intracellular protein catabolism .
Cathepsin L may refer to: Cathepsin L1 , a human protease enzyme encoded by the CTSL gene and known for its role in viral entry Cathepsin L2 , a human protease enzyme encoded by the CTSV gene and also known as cathepsin V
Papain, also known as papaya proteinase I, is a cysteine protease (EC 3.4.22.2) enzyme present in papaya (Carica papaya) and mountain papaya (Vasconcellea cundinamarcensis).It is the namesake member of the papain-like protease family.
This may have different consequences, depending on the normal function of the serine protease. For example, mutations in protein C can lead to protein C deficiency and predisposing to thrombosis . Also, some proteases play a vital role in host cell-virus fusion activation by priming virus's Spike protein to show the protein named "fusion ...
Cathepsin L2 (EC 3.4.22.43, also known as cathepsin V or cathepsin U) is a protein encoded in humans by the CTSV gene. [5] [6] [7] [8]The protein is a human cysteine cathepsin, a lysosomal cysteine protease with endopeptidase activity.
An L-series is a Dirichlet series, usually convergent on a half-plane, that may give rise to an L-function via analytic continuation. The Riemann zeta function is an example of an L -function, and some important conjectures involving L -functions are the Riemann hypothesis and its generalizations .