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Psoriatic erythroderma can be congenital or secondary to an environmental trigger. [12] [13] [14] Environmental triggers that have been documented include sunburn, skin trauma, psychological stress, systemic illness, alcoholism, drug exposure, chemical exposure (e.g., topical tar, computed tomography contrast material), and the sudden cessation of medication.
The history of psoriasis is littered with treatments of dubious effectiveness and high toxicity. In the 18th and 19th centuries, Fowler's solution, which contains a poisonous and carcinogenic arsenic compound, was used by dermatologists as a treatment for psoriasis. [130] Mercury was also used for psoriasis treatment during this time. [130]
However, today the treatment can be done with reduced cost as an outpatient. It has been stated by de Miguel et al., that an annual three-week outpatient course of Goeckerman treatment costs $10,000 to 12,000 but repeat treatment may be extended to two years with the use of a $2,000 home UVB treatment lamp . [ 6 ]
Psoriasis is a skin condition characterized by the rapid buildup of skin cells, leading to scaling on the skin's surface. Inflammation and redness around the scales is common. [27] Some individuals with psoriasis also develop psoriatic arthritis, which causes joint pain, stiffness, and swelling. [28]
Psoriatic arthritis (PsA) is a long-term inflammatory arthritis that occurs in people affected by the autoimmune disease psoriasis. [1] [2] The classic features of psoriatic arthritis include dactylitis (sausage-like appearance), skin lesions, and nail lesions. [3]
The Psoriasis Index of Quality of Life (PSORIQOL) was published in 2003 by Galen Research. [3] The development of the PSORIQOL was a joint effort between the University of Verona, Erasmus University Rotterdam and the University of Sheffield. The content of the PSORIQOL was derived from 62 qualitative interviews with psoriasis patients.
According to the National Psoriasis Foundation, coal tar is a valuable, safe and inexpensive treatment option for millions of people with psoriasis and other scalp or skin conditions. [45] According to the FDA, coal tar concentrations between 0.5% and 5% are considered safe [46] and effective for psoriasis.
Adalimumab, sold under the brand name Humira and others, is a disease-modifying antirheumatic drug and monoclonal antibody used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa, and uveitis.
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