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An antiemetic is a drug that is effective against vomiting and nausea.Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics, and chemotherapy directed against cancer.
Since then, non-peptide NK 1 receptor antagonists have been researched extensively and many structures and patents have appeared. Proposing the concept in the early 1990s, in 1998 Kramer, et al. , reported clinical data on the efficacy and safety of MK-869 (aprepitant) in patients with major depressive disorder. [ 1 ]
[1] [2] This deviation from linearity is described as the non-linear effect, NLE. [3] The linearity can be expressed mathematically , as shown in Equation 1. Stereoselection (i.e. the ee product ) that is higher or lower than the enantiomeric excess of the catalyst (ee catalyst , relative to the equation) is considered non-routine behavior.