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Like all fluoroquinolones, levofloxacin is a fluorinated quinolone carboxylic acid. It is a chiral molecule and the pure (−)-(S)-enantiomer of the racemic drug ofloxacin. [57] [58] [59] This enantiomer binds more effectively to the DNA gyrase enzyme and to topoisomerase IV than its (+)-(R)-counterpart. [54]
Fluoroquinolones have varying specificity for cytochrome P450, so may have interactions with drugs cleared by those enzymes; the order from most P450-inhibitory to least, is enoxacin > ciprofloxacin > norfloxacin > ofloxacin, levofloxacin, trovafloxacin, gatifloxacin, moxifloxacin.
Among the fluoroquinolones, ciprofloxacin and levofloxacin are used more frequently for the treatment of UTIs. These agents are well-absorbed orally and achieve significant concentrations in urine and various tissues. [12] However, fluoroquinolones administration carries risk of GI symptoms, confusion, hypersensitivity, tendinopathy, and ...
Levofloxacin, which is marketed under the brand name Levaquin in the U.S. and Tavanic in the EU, is often prescribed for pneumonia, urinary tract infections and infections of the abdomen.
The overall frequency of fluoroquinolone-associated Achilles tendon rupture in patients treated with ciprofloxacin or levofloxacin has been estimated at 17 per 100,000 treatments. [21] [22] Risk is substantially elevated in the elderly and in those with recent exposure to topical or systemic corticosteroid therapy.
Fluoroquinolones: particularly levofloxacin ... All aminoglycosides are ineffective when taken orally as the stomach will digest the drug before it goes into the ...
This is the first class of non-opioid pain medication approved to treat moderate to severe acute pain approved by the FDA in more than 20 years. The U.S. Food and Drug Administration (FDA) on ...
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