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Nonetheless, ESCs express very high levels of the iPS inducing genes and these genes including Myc are essential for ESC self-renewal and pluripotency, [47] and potential strategies to improve safety by eliminating c-Myc expression are unlikely to preserve the cells' "stemness". However, N-myc and L-myc have been identified to induce iPS cells ...
In in vitro experiments of mouse embryonic stem cells, Oct-4 has often been used as a marker of stemness, as differentiated cells show reduced expression of this marker. Oct3/4 can both repress and activate the promoter of Rex1. In cells that already express high level of Oct3/4, exogenously transfected Oct3/4 will lead to the repression of ...
Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc , l-myc , and n-myc . c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc.
6657 20674 Ensembl ENSG00000181449 ENSMUSG00000074637 UniProt P48431 P48432 RefSeq (mRNA) NM_003106 NM_011443 RefSeq (protein) NP_003097 NP_035573 Location (UCSC) Chr 3: 181.71 – 181.71 Mb Chr 3: 34.7 – 34.71 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self ...
16600 Ensembl ENSG00000136826 ENSMUSG00000003032 UniProt O43474 Q60793 RefSeq (mRNA) NM_001314052 NM_004235 NM_010637 RefSeq (protein) NP_001300981 NP_004226 NP_034767 Location (UCSC) Chr 9: 107.48 – 107.49 Mb Chr 4: 55.53 – 55.53 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Krüppel-like factor 4 (KLF4 ; gut-enriched Krüppel-like factor or GKLF) is a member of the KLF family ...
This is mutually exclusive with alterations at Myc and BRG1, the latter coding for an ATPase of the SWI/SNF complex. It was demonstrated that the BRG1 product regulates the expression of Max through direct recruitment to the Max promoter region, and that depletion of BRG1 strongly hinders cell growth, specifically in Max-deficient cells ...
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[KLF4] is one of the so-called magic four transcription factors, KLF4, Oct4, Sox2 and Myc. KLF5, like KLF3, is important in adipocytes [11] and KLF6 is an important tumour suppressor gene, that is often mutated in prostate cancers. [12]