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Having paid a fee under the Prescription Drug User Fee Act, Orexigen was given a deadline for the FDA to approve or reject the drug of January 2011. In December 2010, an FDA Advisory Committee voted 13-7 for the approval of Contrave and voted 11-8 for the conduct of a post-marketing cardiovascular outcomes study. [18]
Naltrexone-bupropion (Contrave®). This medication combines two drugs: bupropion (an antidepressant that may suppress appetite) and naltrexone, which is used to treat addiction. The combination is ...
In medicine, a contraindication is a condition (a situation or factor) that serves as a reason not to take a certain medical treatment due to the harm that it would cause the patient. [ 1 ] [ 2 ] Contraindication is the opposite of indication , which is a reason to use a certain treatment.
In the United States, a boxed warning (sometimes "black box warning", colloquially) is a type of warning that appears near the beginning of the package insert for certain prescription drugs, so called because the U.S. Food and Drug Administration specifies that it is formatted with a 'box' or border around the text [1] to emphasize its ...
The future of the obesity drug business took a hit on Tuesday when the last of a slate of three proposed new diet drugs, Orexigen's (OREX) Contrave, was rejected by the Food and Drug ...
Then his doctor prescribed the drug Contrave and his life changed. Image Provided by Tim Nicaise. Nurse practitioner Tim Nicaise reached 300 pounds before turning to anti-obesity medication.
Naltrexone, sold under the brand name Revia among others, is a medication primarily used to manage alcohol use or opioid use disorder by reducing cravings and feelings of euphoria associated with substance use disorder. [8]
The mechanism of action of bupropion in the treatment of depression and for other indications is unclear. [2] However, it is thought to be related to the fact that bupropion is a norepinephrine–dopamine reuptake inhibitor (NDRI) and negative allosteric modulator of several nicotinic acetylcholine receptors . [ 2 ]