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The retrograde axonal transport of Rabies lyssavirus to the central nervous system (CNS) is the key step of pathogenesis during natural infection. The exact molecular mechanism of this transport is unknown although binding of the P protein from Rabies lyssavirus to the dynein light chain protein DYNLL1 has been shown. [28]
Rabies is a viral disease that causes encephalitis in humans and other mammals. [1] It was historically referred to as hydrophobia ("fear of water") due to the symptom of panic when presented with liquids to drink. Early symptoms can include fever and abnormal sensations at the site of exposure. [1]
Post-exposure prophylaxis, also known as post-exposure prevention (PEP), is any preventive medical treatment started after exposure to a pathogen in order to prevent the infection from occurring. It should be contrasted with pre-exposure prophylaxis, which is used before the patient has been exposed to the infective agent.
Negri was convinced the inclusions were a parasitic protozoon and the etiologic agent of rabies. Later that same year, however, Paul Remlinger and Rifat-Bey Frasheri in Constantinople and, separately, Alfonso di Vestea in Naples showed that the etiologic agent of rabies is a filterable virus. Negri continued until 1909 to try to prove that the ...
The virions are about 75 nm wide and 180 nm long. [2] Rhabdoviruses are enveloped and have helical nucleocapsids and their genomes are linear, around 11–15 kb in length. [5][2] Rhabdoviruses carry their genetic material in the form of negative-sense single-stranded RNA. They typically carry genes for five proteins: large protein (L ...
Animals with "dumb" rabies appear depressed, lethargic, and uncoordinated. Gradually they become completely paralyzed. When their throat and jaw muscles are paralyzed, the animals will drool and have difficulty swallowing. In animals, rabies is a viral zoonotic neuro-invasive disease which causes inflammation in the brain and is usually fatal.
The rabies vaccine is a vaccine used to prevent rabies. [11] There are several rabies vaccines available that are both safe and effective. [11] Vaccinations must be administered prior to rabies virus exposure or within the latent period after exposure to prevent the disease. [12] Transmission of rabies virus to humans typically occurs through a ...
In epidemiology, a disease vector is any living [1] agent that carries and transmits an infectious pathogen such as a parasite or microbe, to another living organism. [2][3] Agents regarded as vectors are mostly blood-sucking insects such as mosquitoes. The first major discovery of a disease vector came from Ronald Ross in 1897, who discovered ...