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The mitotic index is a measure of cellular proliferation. [1] It is defined as the percentage of cells undergoing mitosis in a given population of cells. Mitosis is the division of somatic cells into two daughter cells. Durations of the cell cycle and mitosis vary in different cell types. An elevated mitotic index indicates more cells are dividing.
CellCognition uses a computational pipeline which includes image segmentation, object detection, feature extraction, statistical classification, tracking of individual cells over time, detection of class-transition motifs (e.g. cells entering mitosis), and HMM correction of classification errors on class labels.
Cells in the mitotic phase are identified by the typical appearance of their chromosomes in the cell during the mitotic phase of the cell cycle. [4] Usually the number of mitotic figures is expressed as the total number in a defined number of high power fields, such as 10 mitoses in 10 high power fields.
In histopathology, the mitosis rate (mitotic count or mitotic index) is an important parameter in various types of tissue samples, for diagnosis as well as to further specify the aggressiveness of tumors. For example, there is routinely a quantification of mitotic count in breast cancer classification. [74]
The Neuronal cell cycle represents the life cycle of the biological cell, its creation, reproduction and eventual death. The process by which cells divide into two daughter cells is called mitosis.
Binucleated cells are cells that contain two nuclei.This type of cell is most commonly found in cancer cells and may arise from a variety of causes. Binucleation can be easily visualized through staining and microscopy.
Mad1 localises predominantly at unattached kinetochores and triggers mitotic arrest in case of a single unattached kinetochore. Mad1 recruits the important SAC component Mad2 to unattached kinetochores and induces mitotic arrest signal amplification. There is a pool of free cytoplasmic Mad2 in its inactive open conformation called o-MAD2.
The presence of multipolar spindles in cancer cells is one of many differences from normal cells which can be seen under a microscope.Cancer is defined by uncontrolled cell growth and malignant cells can undergo cell division with multipolar spindles because they can group multiple centrosomes into two spindles.