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This anti-histidyl tRNA Synthetase antibody is commonly seen in patients with pulmonary manifestations of the syndrome. The following are other possible antibodies that may be seen in association with antisynthetase syndrome: Anti-PL-7, Anti-PL-12, Anti-EJ, Anti-OJ, Anti-KS, Anti-Zo, Anti-Ha (YRS, Tyr). [33]
It has also been classified as an idiopathic inflammatory myopathy, along with polymyositis, necrotizing autoimmune myositis, cancer-associated myositis, and sporadic inclusion body myositis. [24] A form of this disorder that occurs prior to adulthood is known as juvenile dermatomyositis. [25]
Polymyositis and the associated inflammatory myopathies have an associated increased risk of cancer. [3] The features they found associated with an increased risk of cancer were older age, age greater than 45, male sex, difficulty swallowing, death of skin cells, cutaneous vasculitis, rapid onset of myositis (<4 weeks), elevated creatine kinase, higher erythrocyte sedimentation rate and higher ...
Scleromyositis, is an autoimmune disease (a disease in which the immune system attacks the body). People with scleromyositis have symptoms of both systemic scleroderma and either polymyositis or dermatomyositis, and is therefore considered an overlap syndrome.
From eczema to allergic reactions to bug bites, here’s what common skin rashes look like in photos, and the symptoms that can help you ID the condition. ... 24/7 Help. For premium support please ...
On the hands and face, the rash very closely resembles allergies, eczema, fifth disease, or other more common skin condition, but the heliotrope color is unique to the inflammatory process of JDMS. Some children develop calcinosis, which are calcium deposits under the skin. The rash is the source of the "dermato-" part of the name of the disease.
The sharp criteria also excludes anyone with a positive anti-Sm antibody. [69] It has a sensitivity of 42% [70] and a specificity of 87.7%. [32] Major criteria: [69] Myositis; Pulmonary involvement: Diffusion capacity < 70% of normal values; Pulmonary hypertension; Proliferative vascular lesions on lung biopsy; Raynaud's phenomenon or ...
Myositis is a rarely-encountered medical condition characterized by inflammation affecting the muscles. [2] The manifestations of this condition may include skin issues, muscle weakness, and the potential involvement of other organs. [3] Additionally, systemic symptoms like weight loss, fatigue, and low-grade fever can manifest in individuals ...