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Ephedra is widely used by athletes as a performance-enhancing drug, [13] despite a lack of evidence that it improves athletic performance. [14] [15] Ephedra may also be used as a precursor in the illicit manufacture of methamphetamine. [16] Ephedra has been used as a weight-loss aid, sometimes in combination with aspirin and caffeine.
In the United States, it is illegal to market products containing ephedrine or ephedra alkaloids as a dietary supplement. [1] In 2004, ephedra , a botanical source of ephedrine alkaloids, was banned by the U.S. Food and Drug Administration due to serious safety concerns, injuries, and deaths linked to ephedra-containing supplements.
TrimSpa was a dietary supplement designed for weight loss, marketed by the company Goen Technologies and headed by Alexander Szynalski. [1] The ephedra-based supplement was marketed by TrimSpa to help "stave off hunger", [2] until ephedra was banned from the United States. TrimSpa's parent company, Goen Technologies, filed for bankruptcy ...
Ephedrine Sulphate (1932), Ephedrine Compound (1932), and Swan-Myers Ephedrine Inhalant No. 66 (circa 1940).Ephedrine is a non-catecholamine sympathomimetic with cardiovascular effects similar to those of adrenaline/epinephrine: increased blood pressure, heart rate, and contractility.
Ephedrine, one of the most well-known selective NRAs.. A norepinephrine releasing agent (NRA), also known as an adrenergic releasing agent, is a catecholaminergic type of drug that induces the release of norepinephrine (noradrenaline) and epinephrine (adrenaline) from the pre-synaptic neuron into the synapse.
Amphetamine, the parent compound of amphetamine-type stimulants was first synthesized by Romanian chemists Lazar Edeleano in 1887. Around the same time, amphetamine's precursor ephedrine was also abstracted from a Chinese herbal medicine ephedra by a Japanese Chemist. [5]
It is now part of Sanofi. [1] Dexatrim formula has changed considerably over the years. In prior formulations, Dexatrim contained the decongestant phenylpropanolamine (PPA) and the amphetamine-like compound ephedra. [13] A 2000 study by Yale University School of Medicine showed an increased risk of hemorrhagic stroke with taking PPA. [14]
Stacker 2 is an energy supplement company developed by NVE Pharmaceuticals in 1997. It got its name from "Stacking" which was what bodybuilders routinely engaged in by stacking and ingesting Ephedrine HCL, caffeine and aspirin to acquire more energy for a workout.