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The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions.
The bZIP domain is 60 to 80 amino acids in length with a highly conserved DNA binding basic region and a more diversified leucine zipper dimerization region. [4] The localization of the leucines are critical for the DNA binding to the proteins.
MafG has a bZIP structure that consists of a basic region for DNA binding and a leucine zipper structure for dimer formation. [5] Similar to other sMafs, MafG lacks any canonical transcriptional activation domains.
bZIP Maf is a domain found in Maf transcription factor proteins. It contains a leucine zipper (bZIP) domain, which mediates the transcription factor's dimerization and DNA binding properties. The Maf extended homology region (EHR) is present at the N-terminus of the protein.
A DNA-binding domain (DBD) ... The bZIP domain contains an alpha helix with a leucine at every 7th amino acid. If two such helices find one another, the leucines can ...
MafF has a bZIP structure that consists of a basic region for DNA binding and a leucine zipper structure for dimer formation. [5] Similar to other sMafs, MafF lacks any canonical transcriptional activation domains.
All members of the Maf family including sMafs have a bZIP structure that consists of the basic region for DNA binding and the leucine zipper structure for dimer formation (Fig. 2). The basic region of each Maf family protein contains a tyrosine residue, which is critical for the unique DNA-binding modes of these proteins (see below for details ...
X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. [ 5 ] [ 6 ] The XBP1 gene is located on chromosome 22 while a closely related pseudogene has been identified and localized to chromosome 5 . [ 7 ]