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Glyceraldehyde 3-phosphate, also known as triose phosphate or 3-phosphoglyceraldehyde and abbreviated as G3P, GA3P, GADP, GAP, TP, GALP or PGAL, is a metabolite that occurs as an intermediate in several central pathways of all organisms. [2] [3] With the chemical formula H(O)CCH(OH)CH 2 OPO 3 2-, this anion is a monophosphate ester of ...
Glyceraldehyde 3-phosphate dehydrogenase (abbreviated GAPDH) (EC 1.2.1.12) is an enzyme of about 37kDa that catalyzes the sixth step of glycolysis and thus serves to break down glucose for energy and carbon molecules.
Phosphorylation allows cells to accumulate sugars because the phosphate group prevents the molecules from diffusing back across their transporter. Phosphorylation of glucose is a key reaction in sugar metabolism. The chemical equation for the conversion of D-glucose to D-glucose-6-phosphate in the first step of glycolysis is given by:
Older terms for glycerol-3-phosphate dehydrogenase include alpha glycerol-3-phosphate dehydrogenase (alphaGPDH) and glycerolphosphate dehydrogenase (GPDH). However, glycerol-3-phosphate dehydrogenase is not the same as glyceraldehyde 3-phosphate dehydrogenase (GAPDH), whose substrate is an aldehyde not an alcohol.
The 4 substrates of this enzyme are D-glyceraldehyde 3-phosphate, phosphate, NAD +, and NADP +, whereas its 4 products are 3-phospho-D-glyceroyl phosphate, NADH, NADPH, and H +. This enzyme belongs to the family of oxidoreductases , specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor.
Glyceraldehyde (glyceral) is a triose monosaccharide with chemical formula C 3 H 6 O 3. It is the simplest of all common aldoses. It is a sweet, colorless, crystalline solid that is an intermediate compound in carbohydrate metabolism. The word comes from combining glycerol and aldehyde, as glyceraldehyde is glycerol with one alcohol group ...
This pathway, called methyl-D-erythritol phosphate (MEP) or non-mevalonate pathway, is responsible for biosynthesis of isoprenoids—molecules required for cell survival in most pathogenic bacteria and hence will be helpful in most usually antibacterial resistant bacteria.
In enzymology, a glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (EC 1.2.1.12) is an enzyme that catalyzes the chemical reaction D-glyceraldehyde 3-phosphate + phosphate + NAD + ⇌ {\displaystyle \rightleftharpoons } 3-phospho-D-glyceroyl phosphate + NADH + H +