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7-Hydroxycannabidiol (7-OH-CBD) is an active metabolite of cannabidiol, generated in the body from cannabidiol by the action of the enzyme CYP2C19. [1] While methods have been developed for its synthetic production, [2] and measurement of levels in the body following consumption of cannabidiol, [3] its pharmacology has been relatively little studied, though it has been found to possess similar ...
On October 31, 2017, the FDA sent warning letters to four CBD marketers, including Stanley Brothers Social Enterprises, LLC (d/b/a CW Hemp), the producer of Charlotte's Web. They were warned "against making medical claims about cannabidiol (CBD). The agency also took issue with the businesses marketing CBD products as dietary supplements". [43]
Cannabidiol (CBD) is a phytocannabinoid, one of 113 identified cannabinoids in cannabis plants, along with tetrahydrocannabinol (THC), and accounts for up to 40% of the plant's extract. [17] Medically, it is an anticonvulsant used to treat multiple forms of epilepsy. [4]
As of 2017, the hemp industry estimated that annual sales of hemp products were around $820 million annually; hemp-derived CBD have been the major force driving this growth. [ 140 ] Despite this progress, hemp businesses in the US have had difficulties expanding as they have faced challenges in traditional marketing and sales approaches.
Research has shown that Humulus lupulus (the plant that makes hops) and Cannabis sativa (also called hemp and marijuana) are closely related, [1] [a] and it may be possible to create novel cultivars of hops that express valuable chemicals similar to commercial hemp.
A CBD cigarette is a cigarette made with hemp instead of purely tobacco, containing cannabidiol (CBD) but a negligible amount of psychoactive tetrahydrocannabinol (THC). The effects [clarify] typically last between 2–3 hours and can take anywhere from seconds to several minutes to set in, making it one of the fastest methods to feel the effects of cannabidiol.
Cannabis edibles with CBD can decrease symptoms of psychosis and anxiety. [25] Edible oils, tinctures, pills, and gummies have been prescribed to people with cancer to potentially improve poor appetite, pain, or weight loss. [27] Cannabis edibles may be effective for muscle spasms and pain. [28]
H4CBD (hydrogenated CBD, tetrahydrocannabidiol) is a cannabinoid that was first synthesized by Alexander R. Todd in 1940 derived from the catalytic hydrogenation of cannabidiol. [ 1 ] H2-CBD and 8,9-dihydrocannabidiol have also been referred to as "hydrogenated CBD", which may cause confusion.