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Oxidative stress mechanisms in tissue injury. Free radical toxicity induced by xenobiotics and the subsequent detoxification by cellular enzymes (termination).. Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. [1]
Hyperglycemia and risk of severe infectious outcomes can even further be complicated by physiological stress. For instance, elevated blood glucose levels can actively contribute to pathophysiology of this disease, by exacerbating existing inflammation, impairing cellular immune responses, and increasing oxidative stress, which can also lead to ...
This may result in significant damage to cell structures. Cumulatively, this is known as oxidative stress. The production of ROS is strongly influenced by stress factor responses in plants, these factors that increase ROS production include drought, salinity, chilling, defense of pathogens, nutrient deficiency, metal toxicity and UV-B radiation.
"This can cause leaky gut syndrome and increase inflammation and oxidative stress," says Alexander. ... Cells become more resistant to insulin as blood sugar levels rise and fall, keeping blood ...
Chronic stress can cause not only debilitating everyday symptoms from fatigue to forgetfulness, but also serious long-term conditions such as heart disease and high blood pressure.
[7] [8] [9] They are also believed to play a causative role in the vascular complications of diabetes mellitus. [10] AGEs arise under certain pathologic conditions, such as oxidative stress due to hyperglycemia in patients with diabetes. [11] AGEs play a role as proinflammatory mediators in gestational diabetes as well. [12]
If left untreated, gestational diabetes can cause high blood sugar levels in the fetus. It can result in a large baby, as excess sugar that the fetus doesn’t need for energy is stored as fat.
Free radical-scavenging ability of antioxidants may reduce the oxidative stress and thus may protect against oxidative damage. [82] Based on observational studies among healthy individuals, antioxidant concentrations were found to be inversely correlated with several biomarkers of insulin resistance or glucose intolerance. [83] [84]