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Ion-exchange resin beads. An ion-exchange resin or ion-exchange polymer is a resin or polymer that acts as a medium for ion exchange, that is also known as an ionex. [1] It is an insoluble matrix (or support structure) normally in the form of small (0.25–1.43 mm radius) microbeads, usually white or yellowish, fabricated from an organic polymer substrate.
The resin is a weak exchanger because it is only partially ionized over most pH values, and an efficient separation with DEAE-C chromatography requires a specific, narrow pH range. [ 8 ] Cellulose, dextran, agarose, and other insoluble complexes are unaffected because they compose inert matrices, hence why they are so often derivatized with ...
The second application example for the MCSGP prototype is the separation of three MAb variants using a preparative weak cation-exchange resin. Although the intermediately eluting MAb variant can only be obtained with 80% purity at recoveries close to zero in a batch chromatographic process, the MCSGP process can provide 90% purity at 93% yield.
Ion-exchange resin beads Ion-exchange column used for protein purification. Ion exchange is a reversible interchange of one species of ion present in an insoluble solid with another of like charge present in a solution surrounding the solid. Ion exchange is used in softening or demineralizing of water, purification of chemicals, and separation ...
Examples of functional groups of Weak ion exchange resins include diethylaminoethyl (DEAE, -C 2 H 4 N(C 2 H 5) 2), which is an anion exchanger, and carboxymethyl (CM, -CH 2-COOH), [35] which is a cation exchanger. These two types of exchangers can maintain the charge density of their columns over a pH range of 5–9.
In the case of a water softener, the cation exchange resin is exchanging sodium (the Na + ion of NaCl) for hardness minerals such as calcium and magnesium. A dealkalizer contains strong base anion exchange resin that exchanges chloride (the Cl – ion of the NaCl) for carbonate (CO − 3), bicarbonate (H C O − 3) and sulfate (SO 2− 4). As ...
For example, probiotics—which are usually sold in the vitamin aisle—sometimes require refrigeration. Also, capsules that contain liquid or oil may deteriorate more quickly than those that don’t.
Dowex chelating resin A-1, also known as Chelex 100, is based on iminodiacetic acid in a styrene-divinylbenzene matrix. Dowex A-1 is available commercially and is widely used to determine general properties of chelating resins such as rate determining step and pH dependence, etc. Dowex A-1 is produced from chloromethylated styrene ...