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A solution to this is using a wetting solution as the liquid vehicle for suspension preparation. [7] Wetting solution increases the dispersal ability of the solid particles by replacing the air film to increase steric hindrance and minimise interactions between solid particles and resulting in a decreased rate of aggregation. [7] [27]
The dosage form for a pharmaceutical contains the active pharmaceutical ingredient, which is the drug substance itself, and excipients, which are the ingredients of the tablet, or the liquid in which the active agent is suspended, or other material that is pharmaceutically inert. Drugs are chosen primarily for their active ingredients.
These include solubilizers, stabilizers, buffers, tonicity modifiers, bulking agents, viscosity enhancers/reducers, surfactants, chelating agents, and adjuvants. If concentrated by evaporation, the drug may be diluted before administration. For IV administration, the drug may be transferred from a vial to an IV bag and mixed with other materials.
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In chemistry, a suspension is a heterogeneous mixture of a fluid that contains solid particles sufficiently large for sedimentation. The particles may be visible to the naked eye , usually must be larger than one micrometer , and will eventually settle , although the mixture is only classified as a suspension when and while the particles have ...
Oral administration of a liquid. In pharmacology and toxicology, a route of administration is the way by which a drug, fluid, poison, or other substance is taken into the body. [1] Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration ...
nothing by mouth / not by oral administration: nil per os o.d., od, OD right eye. once a day (United Kingdom) oculus dexter omne in die o.s., os, OS left eye:
Intravascular administration does not involve absorption, and there is no loss of drug. [4] The fastest route of absorption is inhalation. [5] Absorption is a primary focus in drug development and medicinal chemistry, since a drug must be absorbed before any medicinal effects can take place. Moreover, the drug's pharmacokinetic profile can be ...