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Additionally, Tedizolid was shown to have fewer treatment-related side effects than linezolid and significantly fewer GI side effects. [6] Trius was planning the second Phase 2 trial and expects to report results around the end of Q1 2013 and planned to submit an NDA to the FDA for the drug in the second half of 2013. [7]
Tedizolid phosphate is a phosphate ester prodrug of the active compound tedizolid. It was developed by Cubist Pharmaceuticals , following acquisition of Trius Therapeutics (originator: Dong-A Pharmaceuticals), and is marketed for the treatment of acute bacterial skin and skin structure infections (also known as complicated skin and skin ...
Antibiotics that usually have activity against vancomycin-resistant Enterococcus (VRE): . Linezolid and Tedizolid; Streptogramins such as quinupristin-dalfopristin; Advanced generation tetracyclines: Tigecycline, Omadacycline, Eravacycline
It differs from linezolid by replacement of the morpholine oxygen with a sulfur atom. Like linezolid, sutezolid is a bacterial protein synthesis inhibitor . In preclinical studies, sutezolid demonstrated superior antituberculosis activity compared to linezolid.
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Linezolid is a member of the oxazolidinone class of medications. [10] Linezolid was discovered in the mid-1990s, and was approved for commercial use in 2000. [16] [17] It is on the World Health Organization's List of Essential Medicines. [18] The World Health Organization classifies linezolid as critically important for human medicine. [19]
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