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Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [ 4 ] [ 8 ] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon . [ 9 ]
When to Take Viagra: 30-60 Minutes Before Intimacy, Not Earlier. If you’re planning to have intimacy, it’s best to take your recommended dose of Viagra ahead of time.
Over the last 25 years, (ED) medications like Viagra and Cialis have become common fixtures in bedrooms around the world. ... from a longer duration of action to a reduced risk of side effects.
Viagra usually starts working 30 to 60 minutes after taking it. But simply swallowing the little blue pill won’t automatically make you hard — you still have to be aroused, either through ...
Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
The PDE5 inhibitors sildenafil (Viagra), vardenafil (Levitra) and tadalafil (Cialis) are prescription drugs which are taken by mouth. [10]: 20–21 As of 2018, sildenafil is available in the UK without a prescription. [54]
In clinical trials of Viagra, more than 82 percent of men with ED reported an improvement in their climaxes after using Viagra at a dosage of 100mg (the highest dosage prescribed for ED).
The duration of action of a drug is the length of time that particular drug is effective. [5] Duration of action is a function of several parameters including plasma half-life, the time to equilibrate between plasma and target compartments, and the off rate of the drug from its biological target. [6]
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