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The extreme endpoint of this distribution are the so-called 'monogenic' obesities where most of the impact on body weight can be tied to a mutation in a single gene that runs in a single family. The classic example of such a genetic effect is the presence of mutations in the leptin gene.
[46] [48] A group called "Carry That Weight" organized a "National Day of Action to Carry That Weight" on October 29, 2014, during which students carried mattresses on 130 US campuses and several elsewhere. [49] [50] Sulkowicz received the National Organization for Women's Susan B. Anthony Award and the Feminist Majority Foundation's Ms. Wonder ...
People in the field work toward developing an understanding of how the whole body responds to a food via systems biology, as well as single gene/single food compound relationships. [1] [2] Nutritional genomics or Nutrigenomics is the relation between food and inherited genes, it was first expressed in 2001. [3] [4]
Monogenic obesity is excess weight caused by a mutation in a single gene, as opposed to syndromic obesity not tied to a single gene variation and most obesity, which is caused by multiple genetic and environmental risk factors.
It is also equal to the average contribution to the gene pool of the next generation, made by the same individuals of the specified genotype or phenotype. Fitness can be defined either with respect to a genotype or to a phenotype in a given environment or time. The fitness of a genotype is manifested through its phenotype, which is also ...
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Perilipin-null mice eat more food than wild-type mice, but gain 1/3 less fat than wild-type mice on the same diet; perilipin-null mice are thinner, with more lean muscle mass. [30] Perilipin-null mice also exhibit enhanced leptin production and a greater tendency to develop insulin resistance than wild-type mice.
Gene structure is the organisation of specialised sequence elements within a gene. Genes contain most of the information necessary for living cells to survive and reproduce. [ 1 ] [ 2 ] In most organisms, genes are made of DNA, where the particular DNA sequence determines the function of the gene.
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