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The Journal of Proteome Research is a peer-reviewed scientific journal published since 2002 by the American Chemical Society. [1] Its publication frequency switched from bimonthly to monthly in 2006. The current editor-in-chief is John R. Yates. [2]
It is thought that characterizing the proteome of blood plasma is a daunting challenge. The depth of the plasma proteome encompasses a dynamic range of more than 10 10 between the highest abundant protein (albumin) and the lowest (some cytokines) and is thought to be one of the main challenges for proteomics. [81]
The Human Proteome Project [1] (HPP) is a collaborative effort coordinated by the Human Proteome Organization. [2] Its stated goal is to experimentally observe all of the proteins produced by the sequences translated from the human genome .
A cellular proteome is the collection of proteins found in a particular cell type under a particular set of environmental conditions such as exposure to hormone stimulation. It can also be useful to consider an organism's complete proteome , which can be conceptualized as the complete set of proteins from all of the various cellular proteomes.
The research underpinning the start of the exploration of the whole human proteome in the Human Protein Atlas program was carried out in the late 1990s and early 2000s. A pilot study employing an affinity proteomics strategy using affinity-purified antibodies raised against recombinant human protein fragments was carried out for a chromosome ...
The related suffix -ome is used to address the objects of study of such fields, such as the genome, proteome or metabolome respectively. The suffix -ome as used in molecular biology refers to a totality of some sort; it is an example of a "neo-suffix" formed by abstraction from various Greek terms in -ωμα , a sequence that does not form an ...
Historically, thermal proteome profiling has been assessed using a western blot against a known target of interest. With the advent of high resolution Orbitrap mass spectrometers , this type of experiment can be executed on a proteome -wide scale and stability curves can be generated for thousands of proteins at once.
In 1997 he co-edited the first book on proteomics, 'Proteome Research: New Frontiers in Functional Genomics' (Wilkins et al. (eds), Springer Verlag), which sold more than 4,000 copies. [5] He was a co-founder of the proteomics company Proteome Systems Ltd. It was established in January 1999, and listed on the Australian Securities Exchange in 2004.