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Statins appear to be effective at preventing cardiovascular disease and death in older adults, according to new research. Most clinical trials evaluating statins have not included people 75 and ...
The Scandinavian Simvastatin Survival Study (also known as the 4S study), was a multicentre, randomized, double-blind, placebo-controlled clinical trial, which provided the initial data that supported the use of the cholesterol-lowering drug, simvastatin, in people with a moderately raised cholesterol and coronary heart disease (CHD); that is people who had previously had a heart attack or angina.
Researchers tested simvastatin, later sold by Merck as Zocor, on 4,444 patients with high cholesterol and heart disease. After five years, the study concluded the patients saw a 35% reduction in their cholesterol, and their chances of dying of a heart attack were reduced by 42%. [12] [192] In 1995, Zocor and Mevacor both made Merck over US$1 ...
However, data (post hoc analysis) on atorvastatin has revealed that it may still be beneficial in reducing combined cardiac events, cardiac and all-cause mortality in those with a higher baseline LDL cholesterol >3.75 mmol/L. [50] [unreliable medical source] While the SHARP study suggested that LDL cholesterol-lowering treatments (e.g. statin ...
New research from the University of Hong Kong found that statins effectively lowered the risk of cardiovascular and all-cause mortality among adults 60 years of age and older — including people ...
Use during pregnancy may harm the baby. [6] Like all statins, rosuvastatin works by inhibiting HMG-CoA reductase, an enzyme found in the liver that plays a role in producing cholesterol. [6] Rosuvastatin was patented in 1991 and approved for medical use in the United States in 2003. [6] [7] It is available as a generic medication. [6]
More than one billion people worldwide, in fact, are unaware they have at least a 60% increased risk for cardiovascular disease or death due to elevated Lp(a) levels, according to the recently ...
A 2010 published meta-analysis found for every 255 patients taking a statin for 4 years, one additional case of diabetes would occur whilst preventing 5.4 major coronary events. [27] Some drugs interact with statins in a way that increases the risk of muscle injury called myopathy, characterized by unexplained muscle weakness or pain.