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Neurotrophic keratitis (NK) is a degenerative disease of the cornea caused by damage of the trigeminal nerve, [1] which results in impairment of corneal sensitivity, spontaneous corneal epithelium breakdown, poor corneal healing and development of corneal ulceration, melting and perforation. [2]
Keratitis is a condition in which the eye's cornea, the clear dome on the front surface of the eye, becomes inflamed. [1] The condition is often marked by moderate to intense pain and usually involves any of the following symptoms: pain, impaired eyesight, photophobia (light sensitivity), red eye and a 'gritty' sensation. [2]
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Cenegermin, sold under the brand name Oxervate, also known as recombinant human nerve growth factor, is a recombinant form of human nerve growth factor. [4] Cenegermin is a peripherally selective agonist of the tropomyosin receptor kinase A (TrkA) and low-affinity nerve growth factor receptor (p75NTR).
Corneal ulcer, also called keratitis, is an inflammatory or, more seriously, infective condition of the cornea involving disruption of its epithelial layer with involvement of the corneal stroma. [ 1 ] [ 2 ] [ 3 ] It is a common condition in humans particularly in the tropics and in farming. [ 4 ]
Scleral lenses may be used to improve vision and reduce pain and light sensitivity for people with a growing number of disorders or injuries to the eye, such as severe dry eye syndrome, microphthalmia, keratoconus, [1] corneal ectasia, Stevens–Johnson syndrome, Sjögren's syndrome, [2] aniridia, neurotrophic keratitis (anesthetic corneas), complications post-LASIK, higher-order aberrations ...
Scleral lenses may be used to improve vision and reduce pain and light sensitivity for people with disorders or injuries to the eye, such as severe dry eye syndrome (keratoconjunctivitis sicca), microphthalmia, keratoconus, corneal ectasia, Stevens–Johnson syndrome, Sjögren's syndrome, aniridia, neurotrophic keratitis (anesthetic corneas ...
Keratitis–ichthyosis–deafness syndrome (KID syndrome), also known as ichthyosiform erythroderma, corneal involvement, and deafness, presents at birth/infancy and is characterized by progressive corneal opacification, either mild generalized hyperkeratosis or discrete erythematous plaques, and neurosensory deafness.