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Chlortalidone is considered a first-line medication for treatment of high blood pressure. [2] Some recommend chlortalidone over hydrochlorothiazide. [1] [15] A meta-analysis of randomized controlled trials found that chlortalidone is more effective than hydrochlorothiazide for lowering blood pressure, while the two drugs have similar toxicity.
Chlorthalidone and hydrochlorothiazide are diuretics used to lower blood pressure. Learn more about the primary differences between these two medications.
Hydrochlorothiazide, sold under the brand name Hydrodiuril among others, is a diuretic medication used to treat hypertension and swelling due to fluid build-up. [4] Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in those with a high calcium level in the urine. [4]
A thiazide diuretic, such as chlorthalidone or hydrochlorothiazide, can be used to create mild hypovolemia which encourages salt and water uptake in proximal tubule and thus improve nephrogenic diabetes insipidus. [22] Amiloride has additional benefit of blocking Na uptake.
Loop diuretics usually have a ceiling effect whereby doses greater than a certain maximum amount will not increase the clinical effect of the drug. Also, there is a threshold minimum concentration of loop diuretics that needs to be achieved at the thick ascending limb to enable the onset of abrupt diuresis.
Diabetes drugs are prescribed alongside lifestyle changes, like a healthy eating plan and increased exercise. They can impact your weight in several ways. Some diabetes medications make the ...
In a trial involving 1,032 adults, patients who were on weekly injections showed a 94% reduction in the risk of progression to type 2 diabetes, compared with placebo, Lilly Lilly's weight-loss ...
Thiazide diuretics are effective, recommended as the best first-line drug for hypertension, [52] and are much more affordable than other therapies, yet they are not prescribed as often as some newer drugs. Chlorthalidone is the thiazide drug that is most strongly supported by the evidence as providing a mortality benefit; in the ALLHAT study, a ...