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Tajima's D is a population genetic test statistic created by and named after the Japanese researcher Fumio Tajima. [1] Tajima's D is computed as the difference between two measures of genetic diversity: the mean number of pairwise differences and the number of segregating sites, each scaled so that they are expected to be the same in a neutrally evolving population of constant size.
For example it is used to calculate the Tajima's D neutral evolution statistic. A sequence alignment, produced by ClustalO, of mammalian histone proteins. Sequences are the amino acids for residues 120-180 of the proteins. Residues that are conserved across all sequences are highlighted in grey.
Comparing the value of the Watterson's estimator, to nucleotide diversity is the basis of Tajima's D which allows inference of the evolutionary regime of a given locus.
George Washington Lee (December 25, 1903 – May 7, 1955) was an African-American civil rights leader, minister, and entrepreneur. He was a vice president of the Regional Council of Negro Leadership and head of the Belzoni, Mississippi, branch of the National Association for the Advancement of Colored People. He was assassinated in 1955 in ...
Fumio Tajima was born in Ōkawa, in Japan's Fukuoka prefecture, in 1951. [1] [2] He graduated from high school in 1970, completed his undergraduate degree at Kyushu University in 1976, and received a Master's degree from the same institution in 1978. [3]
Fay and Wu's H is a statistical test created by and named after two researchers Justin Fay and Chung-I Wu. [1] The purpose of the test is to distinguish between a DNA sequence evolving randomly ("neutrally") and one evolving under positive selection.
Tajima's D is based on the expectation that S = theta * x where x is the sum of 1/i for i from 1 to N. Thus, we turn this into a method to estimate theta by noting that theta = E(S)/x. The current version suggests that S/x part is a "normalized" version of segregating sites, and this leads to a mistake in the calculation of D in the example.
George Washington Lee (January 4, 1894 – August 1, 1976) was an African-American soldier, writer, political leader and corporate executive. Born in Heathman, Mississippi in 1894, Lee spent most of his life in Memphis, Tennessee. Lee received numerous citations for his benevolence and civic initiatives.