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In May 2022, U.S. Food and Drug Administration approved dupilumab (Dupixent) to treat eosinophilic esophagitis (EoE) in adults and pediatric patients 12 years and older weighing at least 40 kilograms (which is about 88 pounds) making it the first US FDA approved treatment for EoE.
Dupilumab is the first treatment for eosinophilic esophagitis approved by the U.S. Food and Drug Administration (FDA). [9] Eosinophilic esophagitis is a chronic inflammatory disorder in which eosinophils, a type of white blood cell, are found in the tissue of the esophagus. [9] In adults and adolescents with eosinophilic esophagitis, common ...
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Eosinophilic esophagitis, an immune system reaction to certain foods, allergens or environmental factors, can cause damage to the esophageal lining, leading to swelling, scarring and narrowing of ...
Mepolizumab, sold under the brand name Nucala by GlaxoSmithKline, is a humanized monoclonal antibody used for the treatment of severe eosinophilic asthma, eosinophilic granulomatosis with polyangiitis, and hypereosinophilic syndrome (HES). [5] It recognizes and blocks interleukin-5 (IL-5), a signalling protein of the immune system.
For twelve weeks of treatment in people aged eleven years of age and older with eosinophilic esophagitis [2] Ciltacabtagene autoleucel: Janssen Biotech: Treatment of adults with relapsed or refractory multiple myeloma, who previously received a proteasome inhibitor (PI), an immunomodulatory agent (IMiD) and an anti-CD38 antibody [3 ...
An esophageal food bolus obstruction is a medical emergency caused by the obstruction of the esophagus by an ingested foreign body.. It is usually associated with diseases that may narrow the lumen of the esophagus, such as eosinophilic esophagitis, Schatzki rings, peptic strictures, webs, or cancers of the esophagus; rarely it can be seen in disorders of the movement of the esophagus, such as ...
Beyond COPD, regulatory submissions are underway in chronic rhinosinusitis with nasal polyps, supported by positive Phase 3 data. And we continue advancing a Phase 3 study in eosinophilic esophagitis.
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