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Pseudoephedrine's principal mechanism of action relies on its action on the adrenergic system. [88] [89] The vasoconstriction that pseudoephedrine produces is believed to be principally an α-adrenergic receptor response. [90]
The principal mechanism of action relies on its indirect stimulation of the adrenergic receptor system by increasing activation of α-and β-adrenergic receptors via induction of norepinephrine release. [40] The presence of direct interactions with α-adrenergic receptors is unlikely but still controversial.
Alpha adrenoreceptor ligands mimic the action of epinephrine and norepinephrine signaling in the heart, smooth muscle and central nervous system, with norepinephrine being the highest affinity. The activation of α 1 stimulates the membrane bound enzyme phospholipase C , and activation of α 2 inhibits the enzyme adenylate cyclase .
The mechanisms of sympathomimetic drugs can be direct-acting (direct interaction between drug and receptor), such as α-adrenergic agonists, β-adrenergic agonists, and dopaminergic agonists; or indirect-acting (interaction not between drug and receptor), such as MAOIs, COMT inhibitors, release stimulants, and reuptake inhibitors that increase the levels of endogenous catecholamines.
A decongestant, or nasal decongestant, is a type of pharmaceutical drug that is used to relieve nasal congestion in the upper respiratory tract.The active ingredient in most decongestants is either pseudoephedrine or phenylephrine (the latter of which has disputed effectiveness).
Dr. Aseem Malhotra, a cardiologist and public health campaigner based in London, says Americans' foods are fueling chronic diseases. He shares his warnings and tips with Fox News Digital.
The precise mechanism of action of some stimulants, ... Pseudoephedrine is a sympathomimetic drug of the phenethylamine and amphetamine chemical classes.
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