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  2. Darbepoetin alfa - Wikipedia

    en.wikipedia.org/wiki/Darbepoetin_alfa

    Darbepoetin alfa / d ɑːr b ə ˈ p oʊ ɪ t ɪ n / is a re-engineered form of erythropoietin containing 5 amino acid changes (N30, T32, V87, N88, T90) resulting in the creation of 2 new sites for N-linked carbohydrate addition. It has a 3-fold longer serum half-life compared to epoetin alpha and epoetin beta.

  3. Erythropoiesis-stimulating agent - Wikipedia

    en.wikipedia.org/wiki/Erythropoiesis-stimulating...

    Darbepoetin alfa, which early literature during its development often termed as novel erythropoiesis-stimulating protein (NESP), is a form created by five substitutions (Asn-30, Thr-32, Val-87, Asn-88 and Thr-90) that create two new N-glycosylation sites. [24]

  4. Equianalgesic - Wikipedia

    en.wikipedia.org/wiki/Equianalgesic

    An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]

  5. 3 Amgen Biologics Facing Generic Competition

    www.aol.com/news/2013-05-29-3-amgen-biologics...

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  6. Will This Biotech Approval Start a $100 Billion Trend? - AOL

    www.aol.com/news/2013-09-11-will-this-biotech...

    Hospira announced that the European Commission has approved its biosimilar version of Remicade from Johnson & Johnson and Merck . The approval of the new drug, called Inflectra, marks the first ...

  7. Gene conversion - Wikipedia

    en.wikipedia.org/wiki/Gene_conversion

    Gene conversion is the process by which one DNA sequence replaces a homologous sequence such that the sequences become identical after the conversion. [1] Gene conversion can be either allelic , meaning that one allele of the same gene replaces another allele, or ectopic , meaning that one paralogous DNA sequence converts another.

  8. Epoetin alfa - Wikipedia

    en.wikipedia.org/wiki/Epoetin_alfa

    Epoetin alfa, sold under the brand name Epogen among others, is a human erythropoietin produced in cell culture using recombinant DNA technology. [ 8 ] [ 9 ] Epoetin alfa is an erythropoiesis-stimulating agent. [ 8 ]

  9. List of off-label promotion pharmaceutical settlements

    en.wikipedia.org/wiki/List_of_off-label...

    The following are settlements reached with US authorities against pharmaceutical companies to resolve allegations of "off-label" promotion of drugs. Under the Federal Food, Drug, and Cosmetic Act, it is illegal for pharmaceutical companies to promote their products for uses not approved by the Food and Drug Administration (FDA), and corporations that market drugs for off-label indications may ...

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