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Repeated exposures to 1/10 of the LCt 50 did not produce overt systemic toxicity or significant pathology. [7] MSF can also cause severe skin burns and serious eye damage, if contact is made. It is a lachrymator and its vapor causes tears in eyes. [8] [2] Methanesulfonyl fluoride has a pungent odor.
PMSF does not inactivate all serine proteases. [1] The effective concentration of PMSF is between 0.1 - 1 mM. The half-life is short in aqueous solutions (110 min at pH 7, 55 min at pH 7.5, and 35 min at pH 8, all at 25 °C). [2] At 4˚C, pH 8, PMSF is almost completely degraded after 1 day. [2]
2.5 mg/kg (mice, intraperitoneal) [1] Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references
For VX, the median lethal dose (LD 50) for 70 kg men via exposure to the skin is estimated to be 10 mg, and the lethal concentration time (LCt 50), measuring the concentration of the vapor per length of time exposed, is estimated to be 30–50 mg·min/m 3. [5] These values for EA-3990 can be estimated to be 3.3 mg and 10–16.7 mg·min/m 3 by ...
Methanesulfonyl chloride is mainly used to give methanesulfonates by its reaction with alcohols in the presence of a non-nucleophilic base. [8] In contrast to the formation of toluenesulfonates from alcohols and p-toluenesulfonyl chloride in the presence of pyridine, the formation of methanesulfonates is believed to proceed via a mechanism wherein methanesulfonyl chloride first undergoes an ...
Related to mesylate is the mesyl (Ms) or methanesulfonyl (CH 3 SO 2) functional group. The shortened term itself was coined by Helferich et al. in 1938 similarly to tosyl adopted earlier. [ 4 ] Methanesulfonyl chloride is often referred to as mesyl chloride.
3.15 mg/kg (mice, subcutaneous) Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references
Like other fluoroquinolones, marbofloxacin has demonstrated a significant post-antibiotic effect for both gram– and + bacteria and is active in both stationary and growth phases of bacterial replication. [3] It has good activity against many gram-negative bacilli and cocci, is effective against: