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  2. Management of depression - Wikipedia

    en.wikipedia.org/wiki/Management_of_depression

    The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...

  3. Pharmacology of antidepressants - Wikipedia

    en.wikipedia.org/wiki/Pharmacology_of...

    The pharmacology of antidepressants is not entirely clear.. The earliest and probably most widely accepted scientific theory of antidepressant action is the monoamine hypothesis (which can be traced back to the 1950s), which states that depression is due to an imbalance (most often a deficiency) of the monoamine neurotransmitters (namely serotonin, norepinephrine and dopamine). [1]

  4. List of antidepressants - Wikipedia

    en.wikipedia.org/wiki/List_of_antidepressants

    This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.

  5. VRC-50 - Wikipedia

    en.wikipedia.org/wiki/VRC-50

    VRC-50 C-2A from USS Enterprise VRC-50 C-130F Hercules at NAS Atsugi VRC-50 US-3A on USS Abraham Lincoln in 1993. 2 October 1969, C-2A #152796 crashed on approach to the USS Constellation on a flight from NAS Cubi Point, all 26 passengers and crew were listed as killed in action, the bodies were not recovered.

  6. Selective serotonin reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Selective_serotonin...

    Treatment guidelines from the National Institute of Health and Clinical Excellence [38] recommend against the use of SSRIs in this disorder. Those from the American Psychiatric Association note that SSRIs confer no advantage regarding weight gain, but that they may be used for the treatment of co-existing depression, anxiety, or OCD. [39]

  7. Antidepressant - Wikipedia

    en.wikipedia.org/wiki/Antidepressant

    According to National Institute for Health and Care Excellence (NICE) guidelines, antidepressants for children and adolescents with depression and obsessive-compulsive disorder (OCD) should be prescribed together with therapy and after being assessed by a child and adolescent psychiatrist. However, between 2006 and 2017, only 1 in 4 of 12–17 ...

  8. Serotonin–norepinephrine–dopamine reuptake inhibitor

    en.wikipedia.org/wiki/Serotonin–norepinephrine...

    These drugs inhibit the uptake of the neurotransmitter 5-HT by blocking the SERT, thus increasing its synaptic concentration, and have shown to be efficacious in the treatment of depression, however sexual dysfunction and weight gain are two very common side-effects that result in discontinuation of treatment.

  9. Tricyclic antidepressant - Wikipedia

    en.wikipedia.org/wiki/Tricyclic_antidepressant

    The first widely used psychiatric drug, by 1955 it was already generating significant revenue as an antipsychotic. [60] Research chemists quickly began to explore other derivatives of chlorpromazine. The first TCA reported for the treatment of depression was imipramine, a dibenzazepine analogue of chlorpromazine code-named G22355. It was not ...

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