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Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies. [5] This includes allergic rhinitis (hay fever) and hives . [ 5 ] It is also available in drug combinations such as loratadine/pseudoephedrine , in which it is combined with pseudoephedrine , a nasal decongestant . [ 5 ]
The maximum total daily dose of pseudoephedrine is 240 ... — contains 120 mg of pseudoephedrine sulfate (also 5 mg of loratadine). Claritin-D 24 Hour ...
A Clarinase Repetab tablet contains 5 mg loratadine in the tablet coating and 120 mg pseudoephedrine sulfate equally distributed between the tablet coating and the barrier-coated core. The two active components in the coating are quickly liberated; release of pseudoephedrine in the core is delayed for several hours.
The maximum dose is used, rather than a lower dose, to reduce the number of test subjects (and, among other things, the cost of testing), to detect an effect that might occur only rarely. This type of analysis is also used in establishing chemical residue tolerances in foods. Maximum tolerated dose studies are also done in clinical trials.
These components of loratadine's structure preclude significant CNS penetration and subsequent sedation and anticholinergic effects. 2 — Loratadine: A Nonsedating Antihistamine with Once-Daily Dosing, https://pubmed.ncbi.nlm.nih.gov/2525847/
Bilastine should not be given with, or within 1 hour before or 2 hours after, food as it may reduce its effectiveness. Australian dosing guidelines for Allertine give a maximum dose of 20 mg (one tablet) daily as needed . [16] Dose changes are not required for hepatic or renal impairment. [16]
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