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Alcohol dehydrogenase activity varies between men and women, between young and old, and among populations from different areas of the world. For example, young women are unable to process alcohol at the same rate as young men because they do not express the alcohol dehydrogenase as highly, although the inverse is true among the middle-aged. [37]
On average, for equal body weight, women have a higher body fat percentage than men. Since alcohol is absorbed into body water content, and men have more water in their bodies than women, for women there will be a higher blood alcohol concentration from the same amount of alcohol consumption. [21]
Alcohol education is the planned provision of information and skills relevant to living in a world where alcohol is commonly misused. [3] WHO Global Status Report on Alcohol and Health, highlights the fact that alcohol will be a larger problem in later years, with estimates suggesting it will be the leading cause of disability and death.
The absorption rate of ethanol is typically modeled as a first-order kinetic process depending on the concentration gradient and specific membrane. The rate of absorption is fastest in the duodenum and jejunum, owing to the larger absorption surface area provided by the villi and microvilli of the small intestines.
After tobacco, alcohol accounts for a higher burden of disease than any other drug. Alcohol use is a major cause of preventable liver disease worldwide, and alcoholic liver disease is the main alcohol-related chronic medical illness. [6] Millions of people of all ages, from adolescents to the elderly, engage in unhealthy drinking. [7]
Women develop long-term complications of alcohol dependence more rapidly than do men, women also have a higher mortality rate from alcoholism than men. [47] Examples of long-term complications include brain, heart, and liver damage [48] and an increased risk of breast cancer. Additionally, heavy drinking over time has been found to have a ...
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The level of ethanol consumption that minimizes the risk of disease, injury, and death is subject to some controversy. [16] Several studies have found a J-shaped relationship between alcohol consumption and health, [17] [18] [2] [19] meaning that risk is minimized at a certain (non-zero) consumption level, and drinking below or above this level increases risk, with the risk level of drinking a ...