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Azadirachtin is formed via an elaborate biosynthetic pathway, but is believed that the steroid tirucallol is the precursor to the neem triterpenoid secondary metabolites. Tirucallol is formed from two units of farnesyl diphosphate (FPP) to form a C 30 triterpene, but then loses three methyl groups to become a C 27 steroid.
The ingestion of neem oil is potentially toxic and can cause metabolic acidosis, seizures, kidney failure, encephalopathy and severe brain ischemia in infants and young children. [ 2 ] [ 8 ] [ 9 ] Neem oil should not be consumed alone without any other solutions, particularly by pregnant women, women trying to conceive or children. [ 2 ]
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Azadirachta indica, commonly known as neem, margosa, nimtree or Indian lilac, [3] is a tree in the mahogany family Meliaceae. It is one of the two species in the genus Azadirachta . It is native to the Indian subcontinent and to parts of Southeast Asia , but is naturalized and grown around the world in tropical and subtropical areas.
Here’s how apply neem oil for insect and disease management. Show comments. Advertisement. Advertisement. Holiday Shopping Guides. See all. AOL. The best air purifiers of 2025. AOL.
Representation of nimbin analog N2. Nimbin is a triterpenoid isolated from the neem tree (Azadirachta indica).Nimbin is thought to be responsible for much of the biological activities of neem oil, and is reported to have anti-inflammatory, antipyretic, fungicidal, antihistamine and antiseptic properties. [2]
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