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Infliximab, a chimeric monoclonal antibody, sold under the brand name Remicade among others, is a medication used to treat a number of autoimmune diseases. This includes Crohn's disease , ulcerative colitis , rheumatoid arthritis , ankylosing spondylitis , psoriasis , psoriatic arthritis , and Behçet's disease . [ 23 ]
The incidence of developing these antibodies is highest in patients receiving intermittent therapy with infliximab, and lowest in patient receiving continuous therapy and concomitant immunosuppressive therapy. Some suggest that the presence of these antibodies causes a decrease in efficacy of infliximab and increased risk of infusion reactions.
Infliximab (Remicade) A monoclonal antibody to TNF, proinflammatory cytokine Crohn's disease, rheumatoid arthritis, ankylosing spondylitis: Respiratory infection, fever, hypotension. Predisposes to infections (reactivation of latent TB) Rituximab (Rituxan) A monoclonal antibody to CD20 surface immunoglobulin
An FDA advisory committee just gave a recommendation for a version of Remicade, a drug used to treat autoimmune diseases. A new drug that could save the US billions of dollars just got one step ...
chronic graft-versus-host disease: Azintuxizumab vedotin [28] mab: chimeric/ humanized: CD319: cancer Bamlanivimab [29] mab: human: spike protein receptor binding domain (RBD) of SARS-CoV-2: Emergency Use Authorization (EUA) when used with etesevimab [30] COVID-19: Bapineuzumab [31] mab: humanized: β-amyloid: Alzheimer's disease: Basiliximab ...
The anti-TNF-α monoclonal antibody infliximab is a major biological therapy for inflammatory bowel disease. Biological therapy, the use of medications called biopharmaceuticals or biologics that are tailored to specifically target an immune or genetic mediator of disease, plays a major role in the treatment of inflammatory bowel disease. [1]
Infliximab (trade name Remicade, among others) is a mouse-human chimeric antibody that targets tumor necrosis factor alpha (TNFα), a cytokine in the inflammatory response. It is a monoclonal antibody that inhibits the pro-inflammatory cytokine TNFα. It is administered intravenously and dosed per weight starting at 5 mg/kg and increasing ...
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