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Phenylglycine is the organic compound with the formula C 6 H 5 CH(NH 2)CO 2 H. It is a non-proteinogenic alpha amino acid related to alanine, but with a phenyl group in place of the methyl group. It is a white solid. The compound exhibits some biological activity. [1]
[1] (S)-DHPG has been investigated for therapeutic effects in the treatment of neuronal injury (such as those associated with ischemia or hypoxia), cognitive enhancement, and Alzheimer's disease. [1] 3,5-Dihydroxyphenylglycine can be isolated from the latex of Euphorbia helioscopia. [2] DHGP is also found in vancomycin and related glycopeptides.
4-Hydroxyphenylglycine (HPG) is a non-proteogenic amino acid found in vancomycin and related glycopeptides. HPG is synthesized from the shikimic acid pathway and requires four enzymes to synthesize: [1] Both L- and D-HPG are used in the vancomycin class of antibiotics.
N-Phenylglycine is an organic compound with the formula C 6 H 5 NHCH 2 CO 2 H. This white solid achieved fame as the industrial precursor to indigo dye. [1] It is a non-proteinogenic alpha amino acid related to sarcosine, but with an N-phenyl group in place of N-methyl.
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DAPT is a chemical compound used in the study of the Notch signaling pathway. [1] DAPT is a γ-secretase inhibitor. It indirectly inhibits Notch, which is a substrate for γ-secretase. [2] In a mouse model of Alzheimer's disease, DAPT reduces the levels of beta-amyloid. [3]
Wiswesser line notation (WLN), invented by William J. Wiswesser in 1949, [1] [2] [3] [4] [5] was the first line notation capable of precisely describing complex ...
D 1 and D 2 receptors interact primarily through discrete amino acids in the cytoplasmic regions of each receptor, with no involvement of transmembrane parts. The intracellular loop 3 of the D 2 receptor contains two adjacent arginine residues, while the carboxyl tail of the D 1 receptor possesses two adjacent glutamic acid residues.