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The disease was initially known as jaagsiekte [jɑːχˈsiktə], a word derived from Afrikaans, meaning "chasing sickness", so called because animals are in respiratory distress as if they are out of breath from being chased. [6] It has also been known as sheep pulmonary adenomatosis and ovine pulmonary carcinoma. [7]
JSRV is the virus that is the cause of the contagious lung tumors in sheep called ovine pulmonary adenocarcinoma (OPA). The disease has also been called "jaagsiekte", after the Afrikaans words for "chase" (jaag) and "sickness" (siekte), to describe the respiratory distress observed in an animal out of breath from being chased, indicating the breathing difficulty experienced by infected sheep.
It is caused by the Enzootic nasal tumor virus, a retrovirus similar to Jaagsiekte sheep retrovirus, which causes a similar disease, also in sheep and goats called Ovine pulmonary adenocarcinoma (OPA). [1] Symptoms include nasal discharge, dyspnea, facial deformity, and weight loss. Like OPA, the disease has a very long incubation period and is ...
Tumors form in nose and are contagious. ENTV targets the respiratory system in ovine, specifically the upper-airway epithelial cells. [6] Oncogenesis occurs in the nasal turbinate cells [8] A typical oncogenic virus will cause a mutation in a host cell, causing the transformation of host cells from a protooncogene into an oncogene.
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1.1 Morphological differential diagnosis. 1.2 ... in situ pulmonary ... multiple atypical adenomatous hyperplasia [2] disseminated AAH [3] Histopathological images ...