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  2. Proton-pump inhibitor - Wikipedia

    en.wikipedia.org/wiki/Proton-pump_inhibitor

    [20] [21] [22] In the United States, the Food and Drug Administration (FDA) has advised that over-the-counter PPIs, such as Prilosec OTC, should be used no more than three 14-day treatment courses over one year. [23] [24] Despite their extensive use, the quality of the evidence supporting their use in some of these conditions is variable.

  3. Discovery and development of proton pump inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Pantoprazole was first prepared in April 1985 by a small group of scale-up chemists. It is a dimethoxy-substituted pyridine bound to a fluoroalkoxy substituted benzimidazole. [5] Pantoprazole sodium is available as gastroresistant or delayed release tablets and as lyophilized powder for intravenous use.

  4. Pantoprazole - Wikipedia

    en.wikipedia.org/wiki/Pantoprazole

    The study of pantoprazole began in 1985, and it came into medical use in Germany in 1994. [10] It is available as a generic medication. [5] [11] In 2022, it was the sixteenth most commonly prescribed medication in the United States, with more than 30 million prescriptions.

  5. Muscarinic acetylcholine receptor M2 - Wikipedia

    en.wikipedia.org/wiki/Muscarinic_acetylcholine...

    [13] [14] In the heart, this contributes to a decreased heart rate. They do so by the G βγ subunit of the G protein; G βγ shifts the open probability of K + channels in the membrane of the cardiac pacemaker cells, which causes an outward current of potassium, effectively hyperpolarizing the membrane, which slows down the heart rate.

  6. Cholinergic blocking drug - Wikipedia

    en.wikipedia.org/wiki/Cholinergic_blocking_drug

    Surgery Premedication [8] Inhibit saliva secretion; Maintain normal heartbeat; Myopia Slow down Myopia progression in children. New off-label treatment; Animal studies showed dopamine and DOPAC increase in the chick retina, important in ocular growth and myopia development. [9] Acute symptomatic bradycardia. Increase heart rate, improve signs ...

  7. Cam Ward sits out second half of Miami's loss in Pop-Tarts ...

    www.aol.com/cam-ward-sits-second-half-005109024.html

    Cam Ward sat out the second half of Miami's Pop-Tarts Bowl loss to Iowa State, with the Hurricanes falling 42-41. Social media had a lot to say:

  8. Hypertrophic cardiomyopathy - Wikipedia

    en.wikipedia.org/wiki/Hypertrophic_cardiomyopathy

    Beta blockers are considered first-line agents, as they can slow down the heart rate and decrease the likelihood of ectopic beats. For people who cannot tolerate beta blockers, nondihydropyridine calcium channel blockers such as verapamil can be used, but are potentially harmful in people who also have low blood pressure or severe shortness of ...

  9. Factbox-Important dates to watch as Republicans take control ...

    www.aol.com/news/factbox-important-days-ahead-us...

    jan. 20: Trump will be sworn in on the West Front steps of the Capitol and takes office as the 47th president, only the second president to be reelected after leaving office.

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