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  2. Chromosomal translocation - Wikipedia

    en.wikipedia.org/wiki/Chromosomal_translocation

    In genetics, chromosome translocation is a phenomenon that results in unusual rearrangement of chromosomes. This includes balanced and unbalanced translocation, with two main types: reciprocal, and Robertsonian translocation. Reciprocal translocation is a chromosome abnormality caused by exchange of parts between non-homologous chromosomes. Two ...

  3. Robertsonian translocation - Wikipedia

    en.wikipedia.org/wiki/Robertsonian_translocation

    A Robertsonian translocation. The short arms of the chromosomes (shown on right) are often lost . Robertsonian translocation (ROB) is a chromosomal abnormality where the entire long arms of two different chromosomes become fused to each other. It is the most common form of chromosomal translocation in humans, affecting 1 out of every 1,000 ...

  4. Chromosomal rearrangement - Wikipedia

    en.wikipedia.org/wiki/Chromosomal_rearrangement

    Such changes may involve several different classes of events, like deletions, duplications, inversions, and translocations. Usually, these events are caused by a breakage in the DNA double helices at two different locations, followed by a rejoining of the broken ends to produce a new chromosomal arrangement of genes , different from the gene ...

  5. Translocation - Wikipedia

    en.wikipedia.org/wiki/Translocation

    Translocation may refer to: Chromosomal translocation, a chromosome abnormality caused by rearrangement of parts Robertsonian translocation, a chromosomal rearrangement in pairs 13, 14, 15, 21, and 22; Nonreciprocal translocation, transfer of genes from one chromosome to another; PEP group translocation, a method used by bacteria for sugar uptake

  6. Genetics of Down syndrome - Wikipedia

    en.wikipedia.org/wiki/Genetics_of_Down_syndrome

    The last becomes a translocation carrier, like the parent. Translocation Down syndrome is often referred to as familial Down syndrome. It is the cause of about 4.5% of the observed Down syndromes. [4] It does not show the maternal age effect, and is just as likely to have come from fathers as mothers.

  7. t (11:14) - Wikipedia

    en.wikipedia.org/wiki/T(11:14)

    t(11;14) is a chromosomal translocation which essentially always involves the immunoglobulin heavy locus, also known as IGH in the q32 region of chromosome 14, as well as cyclin D1 which is located in the q13 of chromosome 11 . [2] Specifically, the translocation is at t(11;14)(q13;q32). [3] [4]

  8. Karyotype - Wikipedia

    en.wikipedia.org/wiki/Karyotype

    Karyotypes describe the chromosome count of an organism and what these chromosomes look like under a light microscope. Attention is paid to their length, the position of the centromeres, banding pattern, any differences between the sex chromosomes, and any other physical characteristics. [3]

  9. Chromosome 21 - Wikipedia

    en.wikipedia.org/wiki/Chromosome_21

    Cancers: Rearrangements (translocations) of genetic material between chromosome 21 and other chromosomes have been associated with several types of cancer. For example, acute lymphoblastic leukemia (a type of blood cancer most often diagnosed in childhood) has been associated with a translocation between chromosomes 12 and 21.