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The main strategies for the management of thyroid storm are reducing production and release of thyroid hormone, reducing the effects of thyroid hormone on tissues, replacing fluid losses, and controlling temperature. [5] Thyroid storm requires prompt treatment and hospitalization. Often, admission to the intensive care unit is needed. [21]
The Wolff–Chaikoff effect has been used as a treatment principle against hyperthyroidism (especially thyroid storm) by infusion of a large amount of iodine to suppress the thyroid gland. Iodide was used to treat hyperthyroidism before antithyroid drugs such as propylthiouracil and methimazole were developed.
Thyroid storm [2] Usual onset: 20–50 years old [2] Causes: Graves' disease, multinodular goiter, toxic adenoma, inflammation of the thyroid, eating too much iodine, too much synthetic thyroid hormone [1] [2] Diagnostic method: Based on symptoms and confirmed by blood tests [1] Treatment: Radioiodine therapy, medications, thyroid surgery [1 ...
Thyrotoxicosis factitia (alimentary thyrotoxicosis, exogenous thyrotoxicosis) [1] [2] is a condition of thyrotoxicosis caused by the ingestion [3] of exogenous thyroid hormone. [4] [5] It can be the result of mistaken ingestion of excess drugs, such as levothyroxine [6] and triiodothyronine, [7] or as a symptom of Munchausen syndrome.
Unlike the Wolff–Chaikoff effect, the Plummer effect does not prevent the thyroid from taking up radioactive iodine, e.g. in the case of nuclear emergencies.Therefore, "plummering" with high-dose iodine is only effective in a short time window after the release of radionuclides. [9]
Endocrine disorders are often quite complex, involving a mixed picture of hyposecretion and hypersecretion because of the feedback mechanisms involved in the endocrine system. For example, most forms of hyperthyroidism are associated with an excess of thyroid hormone and a low level of thyroid stimulating hormone. [2]
Treatment of the low levels of potassium in the blood, followed by correction of the hyperthyroidism, leads to complete resolution of the attacks. It occurs predominantly in males of Chinese, Japanese, Vietnamese, Filipino, and Korean descent. [1] TPP is one of several conditions that can cause periodic paralysis. [4]
Around the world, the most common cause of congenital iodine deficiency syndrome (endemic cretinism) [1] is dietary iodine deficiency. Iodine is an essential trace element, necessary for the synthesis of thyroid hormones. Iodine deficiency is the most common preventable cause of neonatal and childhood brain damage worldwide. [11]
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