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In prokaryotes, corepressors are small molecules whereas in eukaryotes, corepressors are proteins. A corepressor does not directly bind to DNA, but instead indirectly regulates gene expression by binding to repressors. A corepressor downregulates (or represses) the expression of genes by binding to and activating a repressor transcription factor.
The nuclear receptor co-repressor 2 is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains.In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions.
Transcriptional repression by corepressors is in many ways conceptually comparable to the mediation of receptor transcriptional activation by coactivators, but has an opposite outcome. Recruitment of corepressors, generally occurring in the absence of ligand, depends on a critical conformation of the receptor AF-2 domain, as well as upon ...
Transcription coregulators that activate gene transcription are referred to as coactivators while those that repress are known as corepressors. The mechanism of action of transcription coregulators is to modify chromatin structure and thereby make the associated DNA more or less accessible to transcription.
20185 Ensembl ENSG00000141027 ENSMUSG00000018501 UniProt O75376 Q60974 RefSeq (mRNA) NM_001190438 NM_001190440 NM_006311 NM_001252313 NM_011308 NM_177229 RefSeq (protein) NP_001177367 NP_001177369 NP_006302 n/a Location (UCSC) Chr 17: 16.03 – 16.22 Mb Chr 11: 62.21 – 62.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The nuclear receptor co-repressor 1 also known as thyroid ...
Experimental Brain Research is a peer-reviewed scientific journal covering research in neuroscience. The journal was established in 1966 and is published by Springer Science+Business Media . According to the Journal Citation Reports , the journal has a 2020 5-year impact factor of 2.166.
Restorative Neurology and Neuroscience is a bimonthly peer-reviewed medical journal published by IOS Press that was established in 1989. The editor-in-chief is Bernhard A. Sabel (Otto von Guericke University Magdeburg), covering pre-clinical or clinical research in the fields of neurology, neuroscience, and neuroregeneration.
Progress in Neurobiology is a monthly peer-reviewed scientific journal covering all aspects of neuroscience, with an emphasis on multidisciplinary approaches. It was established in 1973 and is published by Elsevier. The co-editors-in-chief are Jeannie Chin (Baylor College of Medicine) and Laura Colgin (University of Texas at Austin).