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[2] [3] It was conceived as a large scale DNA sequencing centre to participate in the Human Genome Project, and went on to make the largest single contribution to the gold standard sequence of the human genome. From its inception the institute established and has maintained a policy of data sharing, and does much of its research in collaboration.
The Human Genome Project was started in 1990 with the goal of sequencing and identifying all base pairs in the human genetic instruction set, finding the genetic roots of disease and then developing treatments. It is considered a megaproject. The genome was broken into smaller pieces; approximately 150,000 base pairs in length. [67]
Microfluidic Sanger sequencing is a lab-on-a-chip application for DNA sequencing, in which the Sanger sequencing steps (thermal cycling, sample purification, and capillary electrophoresis) are integrated on a wafer-scale chip using nanoliter-scale sample volumes. This technology generates long and accurate sequence reads, while obviating many ...
It used the Sanger sequencing method, a technology which formed the basis of the "first generation" of DNA sequencers [2] [3] and enabled the completion of the human genome project in 2001. [4] This first generation of DNA sequencers are essentially automated electrophoresis systems that detect the migration of labelled DNA fragments.
One third of the human genome was sequenced for the first time at the Wellcome Trust Sanger Institute, and the data was stored and shared through EMBL-EBI. This was the largest single contribution of any centre to the Human Genome Project, making the Campus and its collaborations uniquely important in the history of genomics. [citation needed]
After Sanger's retirement in 1983, Coulson contributed to the physical mapping and genome sequencing project of the nematode C. elegans, led by John Sulston and Bob Waterston at the LMB and subsequently the Sanger Centre. [1] [3] [2] This effort was the first to produce the complete genome sequence of an animal. [2]
Personalized genomics is the human genetics-derived study of analyzing and interpreting individualized genetic information by genome sequencing to identify genetic variations compared to the library of known sequences. International genetics communities have spared no effort from the past and have gradually cooperated to prosecute research ...
[2] [3] He and his colleagues' discoveries contributed to the successful sequencing of the first DNA-based genome. [4] The method used in this study, which is called the “Sanger method” or Sanger sequencing, was a milestone in sequencing long strand molecules such as DNA. This method was eventually used in the human genome project. [5]
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